Edwardsiella ictaluri Almost Completely Occupies the Gut Microbiota of Fish Suffering from Enteric Septicemia of Catfish (Esc)

To reveal the changes in gut microbiota of yellow catfish after being infected by Edwardsiella ictaluri, 16S rRNA gene high-throughput sequencing technology was used to analyze microbial composition and diversity healthy diseased catfish. The richness fish were significantly lower than those fish. predicted function drastically altered infection E. ictaluri. Fusobacteriota, Proteobacteria, Firmicutes predominant bacterial phyla fish, while Proteobacteria dominant phylum At genus level, dominated Cetobacterium, Plesiomonas, Romboutsia, overwhelmed pathogenic ictaluri (99.22 ± 0.85%), Romboutsia disappeared. This is most characteristic feature intestinal edwardsiellosis. same sequence detected intestine liver anaerobic Gram-positive bacteria decreased, digestive system, immune metabolic functions reduced gut. may be part pathogenesis